CATALYSIS OF ALPHA-HYDROGEN EXCHANGE .9. ISOBUTYRALDEHYDE-2-D EXCHANGE IN PRESENCE OF AMINO ACIDS

被引：9

作者：

HINE, J

MENON, BC

MULDERS, J

FLACHSKA.RL

机构：

[1] Department of Chemistry, Ohio State University, Columbus

[2] School of Chemistry, Georgia Institute of Technology, Atlanta

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1969年 / 34卷 / 12期

关键词：

D O I：

10.1021/jo01264a070

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalysis of the deuterium exchange of isobutyraldehyde-2-d by glycine, β-alanine, γ-ammobutyric acid, δ- aminovaleric acid, and ϵ-aminocaproic acid has been studied in the presence of pyridine and acetate buffers. In all cases there appears to be catalysis due to the reversible formation of an iminium ion from the aldehyde and amino acid followed by the removal of deuterium from the iminium ion by the various bases present. In no case could bimolecular catalysis via the internal attack of the carboxylate anion group be established. © 1969, American Chemical Society. All rights reserved.

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页码：4083 / &

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