ON THE DETECTION OF PARAMAGNETIC SPECIES IN THE ADRIAMYCIN-PERFUSED RAT-HEART - A REAPPRAISAL

被引：2

作者：

KALYANARAMAN, B ^{[1
]}

BAKER, JE ^{[1
]}

机构：

[1] MED COLL WISCONSIN,DEPT CARDIOTHORAC SURG,MILWAUKEE,WI 53226

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 169卷 / 01期

关键词：

D O I：

10.1016/0006-291X(90)91428-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently, L. Costa et al. reported the direct detection of the superoxide anion and other paramagnetic species in the isolated, adriamycin-perfused rat heart [L. Costa et al. (1988) Biochem. Biophys. Res. Commun. 153, 275-280]. We have reevaluated the results of their study and concluded that the ESR parameters of the spectrum obtained from the adriamycin-perfused heart are consistent with that of the peroxyl radical and not with that of the superoxide anion. In addition, the ESR spectrum of the peroxyl radical is very likely produced as an artifact caused by the grinding of myocardial tissue. This artifact may mask the ESR spectra of the adriamycin-derived semiquinone radical and the iron-sulfur protein components of myocardium. © 1990.

引用

页码：30 / 38

页数：9

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