ENDOTHELIN-1 ACUTELY STIMULATES THE SECRETORY ACTIVITY OF RAT ZONA GLOMERULOSA CELLS

被引：33

作者：

MAZZOCCHI, G

MALENDOWICZ, LK

NUSSDORFER, GG

机构：

[1] UNIV PADUA,DEPT ANAT,VIA GABELLI 65,I-35121 PADUA,ITALY

[2] POZNAN MED ACAD,DEPT HISTOL,PL-60781 POZNAN,POLAND

来源：

PEPTIDES | 1990年 / 11卷 / 04期

关键词：

Aldosterone; Dispersed cells; Endothelin-1; Rat; Zona glomerulosa;

D O I：

10.1016/0196-9781(90)90192-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A bolus IV injection of endothelin-1 (ET-1) (0.5 μg·kg-1) decreased PRA, without affecting plasma aldosterone (A) concentration. ET-1 exerted a dose-dependent stimulation of basal secretion of A and corticosterone (B) by dispersed zona glomerulosa (ZG) cells, while it did not affect B production by inner adrenocortical cells. ET-1 notably enhanced the secretory response of dispersed ZG cells to a maximal effective concentration of ACTH, but not of either angiotensin II (ANG-II) or potassium. The conclusion is drawn that ET-1 acutely stimulates ZG in rats, by a mechanism probably similar to that underlying the adrenoglomerulotropic actions of ANG-II and potassium. © 1990.

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页码：763 / 765

页数：3

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