HYPOMAGNESEMIA AND RENAL MAGNESIUM WASTING IN PATIENTS RECEIVING CISPLATIN

被引：313

作者：

SCHILSKY, RL ^{[1
]}

ANDERSON, T ^{[1
]}

机构：

[1] NCI, DIV CANC TREATMENT, PROGRAM CLIN ONCOL, MED BRANCH, BETHESDA, MD 20014 USA

来源：

ANNALS OF INTERNAL MEDICINE | 1979年 / 90卷 / 06期

关键词：

D O I：

10.7326/0003-4819-90-6-929

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We studied renal function and serum electrolytes in 51 patients receiving cisplatin chemotherapy by retrospectively reviewing the charts of 44 patients and prospectively following seven patients. Hypomagnesemia developed in 23 of 44 evaluable patients who were receiving cisplatin. We documented inappropriate renal magnesium wasting in four patients. Two patients required hospitalization for symptomatic hypomagnesemia. We concluded that cisplatin can induce a renal tubular defect in magnesium conservation and serious clinical syndromes of magnesium deficiency.

引用

页码：929 / 931

页数：3

共 25 条

[1] MAGNESIUM CONSERVATION IN THE HUMAN BEING ON A LOW MAGNESIUM DIET [J].

BARNES, BA ;

COPE, O ;

HARRISON, T .

JOURNAL OF CLINICAL INVESTIGATION, 1958, 37 (03) :430-440

[2]

CONNOR TB, 1972, JOHNS HOPKINS MED J, V131, P100

[3]

DENTINO M, 1978, CANCER, V41, P1274, DOI 10.1002/1097-0142(197804)41:4<1274::AID-CNCR2820410410>3.0.CO

[4]

2-F

[5] EFFECTS OF ETHACRYNIC ACID AND FUROSEMIDE ON URINARY CALCIUM PHOSPHATE AND MAGNESIUM [J].

DUARTE, CG .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1968, 17 (10) :867-&

[6] MAGNESIUM DEPLETION IN NORMAL MAN [J].

DUNN, MJ ;

WALSER, M .

METABOLISM, 1966, 15 (10) :884-&

[7]

EKNOYAN G, 1970, J LAB CLIN MED, V76, P257

[8]

GONZALEZVITALE JC, 1977, CANCER, V39, P1362, DOI 10.1002/1097-0142(197704)39:4<1362::AID-CNCR2820390403>3.0.CO

[9]

2-N

[10]

HIGBY DJ, 1973, CANCER CHEMOTH REP 1, V57, P459

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