INFLUX OF UREA DURING BRONCHOALVEOLAR LAVAGE DEPENDS ON THE PERMEABILITY OF THE RESPIRATORY MEMBRANE

被引：22

作者：

VANDEGRAAF, EA

JANSEN, HM

WEBER, JA

KOOLEN, MGJ

OUT, TA

机构：

[1] UNIV AMSTERDAM,ACAD MED CTR,CLIN IMMUNOL LAB,B1-236,MEIBERGDREEF 9,1105 AZ AMSTERDAM,NETHERLANDS

[2] UNIV AMSTERDAM,ACAD MED CTR,DEPT PULM,1105 AZ AMSTERDAM,NETHERLANDS

[3] UNIV AMSTERDAM,ACAD MED CTR,EXPTL & CLIN IMMUNOL LAB,CLB,1105 AZ AMSTERDAM,NETHERLANDS

[4] UNIV AMSTERDAM,ACAD MED CTR,DEPT CLIN CHEM,1105 AZ AMSTERDAM,NETHERLANDS

来源：

CLINICA CHIMICA ACTA | 1991年 / 196卷 / 01期

关键词：

BRONCHOALVEOLAR LAVAGE; EPITHELIAL LINING FLUID; RESPIRATORY MEMBRANE PERMEABILITY; SARCOIDOSIS; BRONCHIAL ASTHMA; PNEUMOCYSTIS CARINII PNEUMONITIS;

D O I：

10.1016/0009-8981(91)90205-Q

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

In 6 healthy controls and 23 patients with pulmonary diseases the influx of urea during bronchoalveolar lavage was measured by comparing the concentrations of albumin and urea in the sequential samples recovered. It varied between -28 and 151-mu-mol/l. In the bronchoalveolar lavage fluid and serum we measured alpha-2-macroglobulin (A2M) and ceruloplasmin (CP). The bronchoalveolar lavage fluid to serum ratios were calculated (QCP and QA2M). QA2M/QCP was taken as a measure of the respiratory membrane permeability; it varied between 0.05 and 0.53. Influx of urea during lavage was higher according as the QA2M/QCP ratio was higher. We conclude that concentrations of substances in the epithelial lining fluid calculated with the urea correction method have to be corrected for the influx of urea.

引用

页码：27 / 40

页数：14

共 20 条

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