3 NEW TYPES OF VIRAL ONCOGENE OF CELLULAR-ORIGIN SPECIFIC FOR HEMATOPOIETIC-CELL TRANSFORMATION

被引：396

作者：

ROUSSEL, M

SAULE, S

LAGROU, C

ROMMENS, C

BEUG, H

GRAF, T

STEHELIN, D

机构：

[1] INST PASTEUR,INSERM,F-59000 LILLE,FRANCE

[2] DEUTSCH KREBSFORSCHUNGSZENTRUM,INST VIRUSFORSCH,D-6900 HEIDELBERG,FED REP GER

来源：

NATURE | 1979年 / 281卷 / 5731期

关键词：

D O I：

10.1038/281452a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The RNAs of seven replication-defective leukaemia virus (DLV) strains contain three types of unique sequences, which correlate with the capacity of a given virus strain to transform erythroblasts, macrophage-like cells and myeloblasts, respectively. These sequences, termed erb, mac and myb, have their counterparts in the normal DNA of avian and mammalian species. Our results indicate that DLVs represent recombinants between a common 'vector' related to a chicken endogenous virus and one of three types of cellular gene possibly involved in haematopoietic differentiation. © 1979 Nature Publishing Group.

引用

页码：452 / 455

页数：4

共 28 条

[1] CHICKEN HEMATOPOIETIC-CELLS TRANSFORMED BY 7 STRAINS OF DEFECTIVE AVIAN LEUKEMIA VIRUSES DISPLAY 3 DISTINCT PHENOTYPES OF DIFFERENTIATION [J].