PROGNOSTIC VALUE OF DNA FLOW-CYTOMETRY IN PARAGANGLIOMAS OF THE CAROTID-BODY

被引:10
作者
SAUTER, ER
HOLLIER, LH
BOLTON, JS
OCHSNER, JL
SARDI, A
机构
[1] ALTON OCHSNER MED FDN & OCHSNER CLIN,DEPT SURG,1514 JEFFERSON HIGHWAY,NEW ORLEANS,LA 70121
[2] ALTON OCHSNER MED FDN & OCHSNER CLIN,NEW ORLEANS,LA 70121
关键词
CAROTID BODY; DNA INDEX; SYNTHETIC PHASE FRACTION (SPF);
D O I
10.1002/jso.2930460304
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A carotid body tumor is a paraganglioma of the carotid bifurcation. Histologic appearance does not correlate with the malignant potential of the lesion, and thus a reliable prognostic marker for these tumors is lacking. To determine whether flow cytometric analysis of paraffin block specimens by DNA index and synthetic phase fraction (SPF) would be of prognostic value, a retrospective chart review of 14 patients with carotid body tumors was performed. Three of 14 tumors were aneuploid and were the only tumors with SPF > 15%. One of 3 patients (33%) with an aneuploid tumor (SPF = 22%) developed a local recurrence; no patient with a diploid tumor developed a recurrence. Two of 3 (67%) patients with aneuploid tumors (SPF = 18%) but only 1 of 11 (9%) with a diploid tumor were symptomatic preoperatively (P = 0.03). DNA index and SPF may help select a subgroup of patients with more aggressive tumors who are at increased risk for recurrence and therefore require closer follow-up.
引用
收藏
页码:151 / 153
页数:3
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