APPEARANCE OF NERVE GROWTH-FACTOR AND ACIDIC FIBROBLAST GROWTH-FACTOR WITH DIFFERENT TIME COURSES IN THE CAVITY-LESIONED CORTEX OF THE RAT-BRAIN

被引：32

作者：

ISHIKAWA, R ^{[1
]}

NISHIKORI, K ^{[1
]}

FURUKAWA, S ^{[1
]}

机构：

[1] KIRIN BREWERY CO LTD,PHARMACEUT LAB,MAEBASHI,JAPAN

来源：

NEUROSCIENCE LETTERS | 1991年 / 127卷 / 01期

关键词：

CORTICAL CAVITY LESION; RAT BRAIN; NERVE GROWTH FACTOR; ACIDIC FIBROBLAST GROWTH FACTOR;

D O I：

10.1016/0304-3940(91)90897-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Time-dependent changes in both nerve growth factor (NGF) and acidic fibroblast growth factor (aFGF) levels in the rat brain after cortical cavity lesioning were examined, by using sensitive enzyme immunoassays (EIA) specific for each factor. In the cavity fluid, the NGF level increased rapidly and temporarily with a sharp peak 16 h after lesioning. A relatively high level was sustained during the next 3-6 days. Contrary to NGF, aFGF was first detectable only 10 days after lesioning, and its level increased gradually until 30 days. These results suggest that NGF and aFGF would play some roles for neuronal repair in different ways.

引用

页码：70 / 72

页数：3

共 15 条

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