CATECHOLAMINES DECREASE LEUKOTRIENE-B4 AND INCREASE THROMBOXANE-B2 SYNTHESIS IN A23187-STIMULATED HUMAN WHOLE-BLOOD

被引：16

作者：

ALANKO, J ^{[1
]}

RIUTTA, A ^{[1
]}

VAPAATALO, H ^{[1
]}

MUCHA, I ^{[1
]}

机构：

[1] HUNGARIAN ACAD SCI,INST ISOTOPES,H-1525 BUDAPEST,HUNGARY

来源：

PROSTAGLANDINS | 1991年 / 42卷 / 03期

基金：

芬兰科学院;

关键词：

D O I：

10.1016/0090-6980(91)90116-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Catecholamines (adrenaline, dopamine, isoprenaline, noradrenaline) and caffeic acid (catecholic compound without adrenergic receptor activity) decreased leukotriene (LT)B4 synthesis in A23187-stimulated human whole blood. Salbutamol, a non-catecholic beta2-adrenergic agonist, did not influence LTB4 synthesis. Catecholamines stimulated thromboxane (TX)B2 synthesis with a concomitant inhibition of LTB4 synthesis; caffeic acid and salbutamol did not stimulate TXB2 synthesis. These results, obtained in A23187-stimulated whole blood, which also takes into account the complex interaction between different cell types, are similar to our previous results with polymorphonuclear leukocytes. Catecholamines show an opposite effect on lipoxygenase and cyclooxygenase pathways, which may give rise to a marked change in LT/TX ratio in physiological or pathological conditions where sufficient concentrations of catecholamines are present.

引用

页码：279 / 287

页数：9

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