CHARACTERIZATION OF THE MAJOR REGULATORY ELEMENT UPSTREAM OF THE HUMAN ALPHA-GLOBIN GENE-CLUSTER

被引：165

作者：

JARMAN, AP ^{[1
]}

WOOD, WG ^{[1
]}

SHARPE, JA ^{[1
]}

GOURDON, G ^{[1
]}

AYYUB, H ^{[1
]}

HIGGS, DR ^{[1
]}

机构：

[1] JOHN RADCLIFFE HOSP,INST MOLEC MED,MRC,MOLEC HAEMATOL UNIT,OXFORD OX3 9DU,ENGLAND

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1991年 / 11卷 / 09期

关键词：

D O I：

10.1128/MCB.11.9.4679

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The major positive regulatory activity of the human alpha-globin gene complex has been localized to an element associated with a strong erythroid-specific DNase I hypersensitive site (HS -40) located 40 kb upstream of the zeta-2-globin mRNA cap site. Footprint and gel shift analyses of the element have demonstrated the presence of four binding sites for the nuclear factor GATA-1 and two sites corresponding to the AP-1 consensus binding sequence. This region resembles one of the major elements of the beta-globin locus control region in its constitution and characteristics; this together with evidence from expression studies suggests that HS -40 is a primary element controlling alpha-globin gene expression.

引用

页码：4679 / 4689

页数：11

共 56 条

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