ROLE OF THE INTERLEUKIN-5 RECEPTOR SYSTEM IN HEMATOPOIESIS - MOLECULAR-BASIS FOR OVERLAPPING FUNCTION OF CYTOKINES

被引:10
作者
TOMINAGA, A [1 ]
TAKAKI, S [1 ]
HITOSHI, Y [1 ]
TAKATSU, K [1 ]
机构
[1] UNIV TOKYO,INST MED SCI,DEPT IMMUNOL,MINATO KU,TOKYO 108,JAPAN
关键词
D O I
10.1002/bies.950140806
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Interleukin 5 (IL-5) is a kind of peptide hormone released from T lymphocytes of mammals infected with microorganisms or parasites. It is an acidic glycoprotein with a molecular mass of 40 to 50 kDa that consists of a homodimer of polypeptides. It controls hematopoiesis so that it increases natural immunity. In the mouse, IL-5 acts on committed B cells to induce differentiation into Ig-producing cells and on common progenitors for CD5+ pre-B cells and CD5+ macrophages to support their survival. The antibodies secreted by CD5+ B cells seem to be responsible for the primary protection against the infection with microorganisms or parasites. It also supports the growth and/or differentiation of eosinophil precursor and mature eosinophils, which can be effective for the removal of parasites in combination with the antibodies against them. Murine IL-5 receptor (IL-5R) consists of two different polypeptide chains; alpha-chain and beta-chain. The IL-5R alpha-chain is 60 kDa protein that binds IL-5 with low affinity. The IL-5R beta-chain is a 130 kDa protein which does not bind IL-5 by itself but is necessary to form the high affinity IL-5R. The beta-chain was identified by using one of the anti-IL-5R mAb and anti-IL-3R mAb as the IL-3R homologue. This beta-chain is also used as the beta-chain of GM-CSF receptor. This fact suggests that there is a common signaling mechanism among these cytokines and efficient cooperation among them. At the same time, these findings may explain the overlapping role of these cytokines in the development of granulocytes.
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页码:527 / 533
页数:7
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