QUALITY-OF-LIFE ASSESSMENT IN CANCER-TREATMENT PROTOCOLS - RESEARCH ISSUES IN PROTOCOL DEVELOPMENT

被引：174

作者：

GOTAY, CC ^{[1
]}

KORN, EL ^{[1
]}

MCCABE, MS ^{[1
]}

MOORE, TD ^{[1
]}

CHESON, BD ^{[1
]}

机构：

[1] NCI,DIV CANC TREATMENT,CANC THERAPY EVALUAT PROGRAM,BETHESDA,MD 20892

来源：

JOURNAL OF THE NATIONAL CANCER INSTITUTE | 1992年 / 84卷 / 08期

关键词：

D O I：

10.1093/jnci/84.8.575

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Interest in incorporating quality of life as an end point in clinical studies of cancer treatment has intensified in recent years. Purpose: We provide practical suggestions that will assist investigators considering including quality-of-life assessment in phase III therapeutic trials. Methods: We discuss issues important in study planning, including quality-of-life definition, priority studies for quality-of-life assessment, eligibility requirements, and design. Conclusions: Many of the problems that quality-of-life studies have encountered, from protocol approval to data analysis, could be addressed and alleviated during protocol development. This discussion is intended to assist and stimulate investigators conducting research in this area.

引用

页码：575 / 579

页数：5

共 39 条

[1] AARONSON NK, 1990, OCT WORKSH QUAL LIF
[2] AARONSON NK, 1987, QUALITY LIFE CANCER, P63
[3] BAROFSKY I, 1990, QUALITY LIFE ASSESSM, P419
[4] THE SICKNESS IMPACT PROFILE - DEVELOPMENT AND FINAL REVISION OF A HEALTH-STATUS MEASURE
BERGNER, M
BOBBITT, RA
CARTER, WB
GILSON, BS
[J]. MEDICAL CARE, 1981, 19 (08) : 787 - 805
[5] BUCCHERI GF, 1989, CANCER, V63, P428, DOI 10.1002/1097-0142(19890201)63:3<428::AID-CNCR2820630305>3.0.CO
[6] 2-V
[7] Calman KC, 1987, QUALITY LIFE CANC PA, P1
[8] CELLA D F, 1988, Comprehensive Therapy, V14, P69
[9] Cella D F, 1990, Oncology (Williston Park), V4, P29
[10] CELLA DF, 1989, P ASCO ONCOL, V8, pA1225

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