INTERACTION OF THE NATURAL ANTI-GAL ANTIBODY WITH ALPHA-GALACTOSYL EPITOPES - A MAJOR OBSTACLE FOR XENOTRANSPLANTATION IN HUMANS

被引：570

作者：

GALILI, U

机构：

[1] Uri Galili is at the Dept of Microbiology and Immunology, The Medical College of Pennsylvania, Philadelphia

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 10期

关键词：

D O I：

10.1016/0167-5699(93)90261-I

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cells of nonprimate mammals express an abundance of the carbohydrate structure Galalpha1-3Galbeta1-4GlcNAc-R (termed the alpha-galactosyl epitope). The natural anti-Gal antibody, which interacts specifically with alpha-galactosyl epitopes, is present in high concentrations in alt humans. Here, Uri Galili argues that the interaction between anti-Gal in the serum and alpha-galactosyl epitopes on celts of nonprimate grafts may act as an immunological barrier which prevents xenotransplantation.

引用

页码：480 / 482

页数：3

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