AEROSOLIZED PROSTACYCLIN IN ADULT-RESPIRATORY-DISTRESS-SYNDROME

被引：228

作者：

WALMRATH, D ^{[1
]}

SCHNEIDER, T ^{[1
]}

PILCH, J ^{[1
]}

GRIMMINGER, F ^{[1
]}

SEEGER, W ^{[1
]}

机构：

[1] UNIV GIESSEN,DEPT INTERNAL MED,KLIN STR 36,W-6300 GIESSEN,GERMANY

来源：

LANCET | 1993年 / 342卷 / 8877期

关键词：

D O I：

10.1016/0140-6736(93)92004-D

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We studied the effects of aerosolised prostacyclin (PGI2) in three patients with acute severe adult respiratory distress syndrome. 17-50 ng/kg per min, nebulised into the afferent limb of the ventilator circuit, decreased mean pulmonary artery pressure (SEM) from 40.3 (13.5) to 32.0 (3.8) mm Hg (pulmonary vascular resistance fell by 30%); systemic arterial pressure decreased slightly from 76.8 (2.2) to 74.5 (6.1) mm Hg. Concomitantly, the ratio of arterial oxygen partial pressure to the fraction of inspired oxygen increased from 120 (19) to 173 (18), mainly due to redistribution of blood flow from shunt areas to regions of normal ventilation-perfusion. All effects were reversed on drug withdrawal.

引用

页码：961 / 962

页数：2

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