INHIBITION OF BASIC CALCIUM-PHOSPHATE CRYSTAL-INDUCED MITOGENESIS BY PHOSPHOCITRATE

被引:20
作者
CHEUNG, HS [1 ]
SALLIS, JD [1 ]
MITCHELL, PG [1 ]
STRUVE, JA [1 ]
机构
[1] UNIV TASMANIA,DEPT BIOCHEM,HOBART,TAS 7001,AUSTRALIA
关键词
D O I
10.1016/0006-291X(90)91350-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Basic calcium phosphate crystals control the traverse of cells from the Go G1 to S-phase of the cell cycle and initiate proliferation by rendering fibroblasts competent to respond to insulin-like growth factors in plasma. Simultaneous addition of phosphocitrate [a powerful inhibitor of hydroxyapatite crystallization] to cells exposed to basic calcium phosphate crystals caused a dose-dependent inhibition of crystal-induced DNA synthesis and c-fos transcription. This inhibition was specific for crystal-induced mitogenesis, since similar concentrations of phosphocitrate had no effects on either PDGF or 10% calf serum-induced thymidine incorporation and c-fos transcription. © 1990.
引用
收藏
页码:20 / 25
页数:6
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