INHIBITION OF BASIC CALCIUM-PHOSPHATE CRYSTAL-INDUCED MITOGENESIS BY PHOSPHOCITRATE

被引：20

作者：

CHEUNG, HS ^{[1
]}

SALLIS, JD ^{[1
]}

MITCHELL, PG ^{[1
]}

STRUVE, JA ^{[1
]}

机构：

[1] UNIV TASMANIA,DEPT BIOCHEM,HOBART,TAS 7001,AUSTRALIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 171卷 / 01期

关键词：

D O I：

10.1016/0006-291X(90)91350-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Basic calcium phosphate crystals control the traverse of cells from the Go G1 to S-phase of the cell cycle and initiate proliferation by rendering fibroblasts competent to respond to insulin-like growth factors in plasma. Simultaneous addition of phosphocitrate [a powerful inhibitor of hydroxyapatite crystallization] to cells exposed to basic calcium phosphate crystals caused a dose-dependent inhibition of crystal-induced DNA synthesis and c-fos transcription. This inhibition was specific for crystal-induced mitogenesis, since similar concentrations of phosphocitrate had no effects on either PDGF or 10% calf serum-induced thymidine incorporation and c-fos transcription. © 1990.

引用

页码：20 / 25

页数：6

共 30 条

[1] GROWTH STIMULATORY PRECIPITATES OF CA-2+ AND PYROPHOSPHATE [J].