SYNTHESIS OF OPTICALLY-ACTIVE BETA-LACTAMS BY THE PHOTOLYTIC REACTION OF IMINES WITH OPTICALLY-ACTIVE CHROMIUM CARBENE COMPLEXES

被引：126

作者：

HEGEDUS, LS

IMWINKELRIED, R

ALARIDSARGENT, M

DVORAK, D

SATOH, Y

机构：

[1] Department of Chemistry, Colorado State University, Colorado, 80523, Fort Collins

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1990年 / 112卷 / 03期

关键词：

D O I：

10.1021/ja00159a034

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Optically active chromium carbene complexes utilizing (S)-valine- and (R)-phenylglycine-derived chiral auxiliaries were synthesized and subjected to photolytic reaction with a number of imines. Optically active β-lactams were produced in good to excellent chemical yield and with high diastereoisomeric excess. Procedures for removal of the chiral auxilliary to produce the optically active free amino β-lactams were developed. © 1990, American Chemical Society. All rights reserved.

引用

页码：1109 / 1117

页数：9

共 21 条

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