COMPARISON OF THE EFFECTS OF ACUTE AND SUB-ACUTE ADMINISTRATION OF BETA-PHENYLETHYLAMINE AND D-AMPHETAMINE ON MOUSE KILLING BEHAVIOR OF RATS

被引：7

作者：

BARR, GA ^{[1
]}

GIBBONS, JL ^{[1
]}

BRIDGER, WH ^{[1
]}

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT PSYCHIAT, BRONX, NY 10461 USA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1979年 / 11卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Aggression; Amphetamine; Food intake; Mouse killing; Muricide; Predatory aggression; Stimulants; Tolerance; β-Phenylethylamine;

D O I：

10.1016/0091-3057(79)90118-7

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

.beta.-Phenethylamine (PEA) is an endogenous amine that in some instances acts biochemically and behaviorally like amphetamine. The effects of PEA on mouse killing by rats were compared and contrasted with the effects of d-amphetamine on this behavior. When given acutely to experienced mouse killing rats, PEA (16 and 32 mg/kg) inhibited killing in a direct dose dependent manner. This is similar to the dose dependent inhibition of killing by amphetamine reported previously. d-Amphetamine but not PEA showed physiologic tolerance following 8 days of twice daily administration. Cross tolerance between the 2 drugs only occurred when d-amphetamine was administered subacutely. PEA and d-amphetamine have similar acute effects but differed when given subacutely since PEA did not show tolerance and there was not bidirectional cross-tolerance. Apparently these drugs have different pharmacologic actions when given repeatedly. One possible difference may be the duration of action.

引用

页码：419 / 422

页数：4

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