SYNTHESIS OF (+/-)-2'-OXA-CARBOCYCLIC-2',3'-DIDEOXYNUCLEOSIDES AS POTENTIAL ANTI-HIV AGENTS

被引：42

作者：

BAMFORD, MJ

HUMBER, DC

STORER, R

机构：

[1] Department of Medicinal Chemistry, Glaxo Group Research Ltd., Greenford

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 02期

关键词：

D O I：

10.1016/0040-4039(91)80873-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel 2',3'-dideoxynucleosides, having the pentofuranosyl oxygen at the 2'-position, were obtained by a short synthetic route from diethyl malonate and bromoacetaldehyde dimethyl acetal. The results of biological testing against HIV-1 in vitro are presented.

引用

页码：271 / 274

页数：4

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