INSITU HYBRIDIZATION ASCERTAINS THE PRESENCE OF A TRANSLOCATION T(6-11) IN AN ACUTE MONOCYTIC LEUKEMIA

被引：23

作者：

DERRE, J

CHERIF, D

LECONIAT, M

JULIER, C

BERGER, R

机构：

[1] INST GENET MOLEC,INSERM,U301,27 RUE JULIETTE DODU,F-75010 PARIS,FRANCE

[2] CTR ETUD POLYMORPHISME HUMAIN,PARIS,FRANCE

[3] INST GENET MOLEC,CNRS,SDI 159341,PARIS,FRANCE

来源：

GENES CHROMOSOMES & CANCER | 1990年 / 2卷 / 04期

关键词：

D O I：

10.1002/gcc.2870020413

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In situ hybridization was performed in a case of acute monoblastic leukemia (FAB type M5b) with a rearrangement of the long arm of chromosome 11. Cytogenetic analysis after R‐ and G‐banding showed an apparent deletion of 11q with a breakpoint at 11q23, and a translocation t(6;11) was suspected in certain metaphases. In situ hybridization with a biotinylated cosmid probe hybridizing at 11q25 confirmed the translocation t(6;11)(q27;q23). Use of nonradioactive in situ hybridization techniques for more precise characterization of chromosomal rearrangements in malignant cells is emphasized. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

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页码：341 / 344

页数：4

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