AN IMPROVED CHEMICAL IONIZATION ASSAY FOR MEVALONIC ACID

被引：8

作者：

HOFFMANN, GF ^{[1
]}

SWEETMAN, L ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT PEDIAT,LA JOLLA,CA 92093

来源：

BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY | 1990年 / 19卷 / 08期

关键词：

D O I：

10.1002/bms.1200190809

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

The determination of mevalonic acid by gas chromatography/mass spectrometry (GC/MS) is complicated by poor extractability and multiple product formation. Reliable quantification down to physiological levels was achieved by isolating mevalonic acid by liquid partition chromatography and quantifying the underivatized lactone by means of ammonia chemical ionization, selected ion monitoring, capillary GC/MS. (2H3)mevalonic acid served as the internal standard. The method appears to be suitable for the study of mevalonic aciduria as well as the evaluation of different therapeutic regimens in patients with hypercholesterolaemia. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：517 / 519

页数：3

共 7 条

[1] MEASUREMENT OF MEVALONATE IN HUMAN-PLASMA AND URINE BY MULTIPLE SELECTED ION MONITORING [J].