PLEIOTROPIC-RESISTANT PHENOTYPE IS A MULTIFACTORIAL PHENOMENON IN HUMAN COLON-CARCINOMA CELL-LINES

被引：52

作者：

TOFFOLI, G

VIEL, A

TUMIOTTO, L

BISCONTIN, G

ROSSI, C

BOIOCCHI, M

机构：

[1] CTR RIFERIMENTO ONCOL, DIV EXPTL ONCOL 1, VIA PEDEMONTANA OCCIDENTALE, I-33081 AVIANO, ITALY

[2] CTR RIFERIMENTO ONCOL, DIV SURG ONCOL, I-33081 AVIANO, ITALY

来源：

BRITISH JOURNAL OF CANCER | 1991年 / 63卷 / 01期

关键词：

D O I：

10.1038/bjc.1991.11

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The biochemical basis of multidrug-resistant (MDR) phenotype has been investigated in drug-resistant sublines independently obtained in our laboratories by single step doxorubicin (DOX) selection of LoVo, DLD1, and SW948 human colon carcinoma (HCC) cell lines. All the chemoresistant sublines have been found to be cross-resistant to DOX, actinomycin-D (ACT-D) and vincristine (VCR) but not to cis-diammine- dichloroplatinum (CDDP), and have exhibited an increased expression level of mdrl mRNA and gp170 glycoprotein. Comparative analyses in drug-resistant and sensitive cells of resistance index, extracellular and intracellular equitoxic DOX concentrations, and mdrl gene products expression have indicated that MDR phenotype is a multifactorial phenomenon due to different and possibly independent biochemical mechanisms which cooperate, in varying degrees from cell line to cell line, in conferring cellular chemoresistance.

引用

页码：51 / 56

页数：6

共 29 条

[1] INTERNAL DUPLICATION AND HOMOLOGY WITH BACTERIAL TRANSPORT PROTEINS IN THE MDR1 (P-GLYCOPROTEIN) GENE FROM MULTIDRUG-RESISTANT HUMAN-CELLS [J].