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PROTEINASE-MEDIATED CARTILAGE DEGRADATION IN OSTEOARTHRITIS

被引：75
作者：
DEAN, DD
机构：
[1] UNIV MIAMI,DEPT MED,MIAMI,FL 33152
[2] UNIV MIAMI,DEPT BIOCHEM MOLEC BIOL,MIAMI,FL 33152
来源：
SEMINARS IN ARTHRITIS AND RHEUMATISM | 1991年 / 20卷 / 06期
关键词：
CARTILAGE DEGRADATION; OSTEOARTHRITIS; PROTEINASES; MATRIX METALLOPROTEINASES; TISSUE INHIBITOR OF METALLOPROTEINASES (TIMP);
D O I：
10.1016/0049-0172(91)90023-S
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Osteoarthritis (OA) is a disease of complex etiology that results in articular cartilage breakdown. Current experimental evidence strongly suggests that proteinases may be involved in this loss of cartilage matrix. The present review summarizes the evidence for implicating proteinases in the etiopathogenesis of OA and suggests that blockade of proteinase activity may provide a rational basis for new therapeutic agents. © 1991.
引用
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页码：2 / 11
页数：10
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