A RAT BETA-INTERFERON-INDUCED MESSENGER-RNA - SEQUENCE CHARACTERIZATION

被引：12

作者：

HAYZER, DJ

BRINSON, E

RUNGE, MS

机构：

[1] Division of Cardiology, Emory University School of Medicined, Atlanta

来源：

GENE | 1992年 / 117卷 / 02期

关键词：

RECOMBINANT DNA; PCR; SEQUENCE COMPARISON;

D O I：

10.1016/0378-1119(92)90739-C

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Polymerase chain reaction amplification of a cDNA derived from rat aortic smooth muscle cells, using sequences from conserved regions of the intramembrane domains of adrenergic receptors as primers, yielded the clone, rat8. This clone possesses a high degree of sequence similarity to a series of human interferon (IFN)-inducible genes. The rat8 sequence is 70% similar to that derived from the human alpha-IFN-induced gene, 9-27; there is 66% similarity between the deduced amino acid sequences encoded by the rat and the human genes. The rat homologue hybridizes with many bands in Southern analysis of rat DNA, suggesting that it is a member of a large multigene family.

引用

页码：277 / 278

页数：2

共 6 条

[1] TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL REGULATION OF INTERFERON-INDUCED GENE-EXPRESSION IN HUMAN-CELLS [J].