NEUROTROPHIN-5 - A NOVEL NEUROTROPHIC FACTOR THAT ACTIVATES TRK AND TRKB

被引：761

作者：

BERKEMEIER, LR

WINSLOW, JW

KAPLAN, DR

NIKOLICS, K

GOEDDEL, DV

ROSENTHAL, A

机构：

[1] GENENTECH INC, DEPT DEV BIOL, San Francisco, CA 94080 USA

[2] NCI, FREDERICK CANC RES & DEV CTR, ABL BASIC RES PROGRAM, MMCL, FREDERICK, MD 21701 USA

来源：

NEURON | 1991年 / 7卷 / 05期

关键词：

D O I：

10.1016/0896-6273(91)90287-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In vertebrates, the formation and maintenance of neuronal connections are subject to regulation by multiple target-derived, diffusible (neurotrophic) factors. Here we describe the identification and characterization of a novel neurotrophic factor designated neurotrophin-5 (NT-5). NT-5 is structurally related to nerve growth factor and is expressed in embryonic as well as adult tissues. Recombinant NT-5 promotes the survival of peripheral sensory and sympathetic neurons and induces differentiation of the pheochromocytoma cell line PC12. NT-5 activates two trk-related tyrosine kinase receptors and shares these receptors with other neurotrophins. Activation of multiple receptors may permit a single neurotrophin to control target innervation by distinct neuronal populations. Receptor sharing could enable neurotrophic factors emanating from distinct targets to cooperate in regulating neurons with multiple connections.

引用

页码：857 / 866

页数：10

共 59 条

[1] CHOLINERGIC NEURONOTROPIC FACTORS - INTRA-OCULAR DISTRIBUTION OF TROPHIC ACTIVITY FOR CILIARY NEURONS [J].