TOWARDS THE SYNTHESIS OF SWINHOLIDE-A AND SCYTOPHYCIN-C - A HIGHLY STEREOCONTROLLED SYNTHESIS OF (-)-PRE-SWINHOLIDE-A

被引：31

作者：

PATERSON, I

CUMMING, JG

SMITH, JD

WARD, RA

YEUNG, KS

机构：

[1] University Chemical Laboratory, Cambridge, CB2 1EW, Lensfield Road

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 20期

关键词：

D O I：

10.1016/S0040-4039(00)76920-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The fully protected monomeric unit 19 of the marine macrodiolide, swinholide A (1), was obtained with >97% ds by a Mukaiyama aldol reaction between 16 and 5, followed by a boron-mediated reduction to give the syn 1,3-diol 18. Deprotection gave (-)-pre-swinholide A (2), the putative biosynthetic precursor of 1.

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页码：3405 / 3408

页数：4

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