ACTIVATION OF THE MAP KINASE HOMOLOG RK REQUIRES THE PHOSPHORYLATION OF THR-180 AND TYR-182 AND BOTH RESIDUES ARE PHOSPHORYLATED IN CHEMICALLY STRESSED KB CELLS

被引：72

作者：

DOZA, YN ^{[1
]}

CUENDA, A ^{[1
]}

THOMAS, GM ^{[1
]}

COHEN, P ^{[1
]}

NEBREDA, AR ^{[1
]}

机构：

[1] IMPERIAL CANC RES FUND,CLARE HALL LABS,S MIMMS EN6 3LD,HERTS,ENGLAND

来源：

FEBS LETTERS | 1995年 / 364卷 / 02期

基金：

英国惠康基金;

关键词：

MAP KINASE; STRESS; ARSENITE; PROTEIN KINASE; PHOSPHOTYROSINE;

D O I：

10.1016/0014-5793(95)00346-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A MAP kinase homologue, termed the reactivating kinase (RK), lies in a signalling pathway which mediates cellular responses to stress, Here vue demonstrate that the stress-induced activation of the RK in human KB cells is accompanied by the phosphorylation of Thr-180 and Tyr-182, and that the phosphorylation of both residues is required for the activation of this enzyme.

引用

页码：223 / 228

页数：6

共 22 条

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