STRUCTURE-ACTIVITY RELATIONS IN AN IMIDAZOLINE SERIES PREPARED FOR THEIR ANALGESIC PROPERTIES

被引：20

作者：

NEELY, WB

WHITE, HC

RUDZIK, A

机构：

[1] Dow Chemical Company, Midland, Michigan

[2] The Upjohn Co, Kalamazoo, Michigan

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1968年 / 57卷 / 07期

关键词：

Imidazolines—synthesis; NMR spectrometry—identity; Pharmacological activity—imidazolines; Reactivity index—molecular orbital technique; Structure‐activity relations—analgesic;

D O I：

10.1002/jps.2600570718

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A specific pharmacological property of a series of substituted imidazolines was examined in an effort to determine the structure‐activity relationships that might be present. The best measure of the chemical reactivity was based on a charge‐transfer complex between the drug and the receptor site. Using the molecular orbital technique for measuring this reactivity index, and combining with the partition coefficient in the manner described by Hansch 94.4 percent correlation was found for the biological activity. Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1176 / &

共 17 条

[1] POTENTIAL ANTIHYPERTENSIVE AGENTS - SOME GUANIDINE DERIVATIVES [J].