FLUIDITY AND LIPID-COMPOSITION OF MOUSE BIOMEMBRANES DURING ADAPTATION TO ETHANOL

被引:40
作者
CHIN, JH
GOLDSTEIN, DB
PARSONS, LM
机构
[1] Department of Pharmacology, Stanford University School of Medicine, Stanford, California
关键词
D O I
10.1111/j.1530-0277.1979.tb04767.x
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Showing that ethanol added in vitro increased the fluidity of mouse erythrocyte and synaptosomal membranes and that the same membranes Isolated from mice after chronic treatment with ethanol had increased cholesterol and were resistant to ethanol in vitro, the study suggests that the animals had adapted to the chronic presence of the drug by changing their membrane lipid composition to offset the fluidizing effects of ethanol. Copyright © 1979, Wiley Blackwell. All rights reserved
引用
收藏
页码:47 / 49
页数:3
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