DISSOLUTION OF MACROMOLECULES .I. SURFACE PHENOMENA ASSOCIATED WITH POLYMER DISSOLTUION

被引：18

作者：

HEYD, A

KILDSIG, DO

BANKER, GS

机构：

[1] Industrial and Physical Pharmacy Department, School of Pharmacy and Pharmacal Sciences, Purdue University, Lafayette, Indiana

[2] School of Pharmacy, University of Connecticut, Storrs, Connecticut

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 05期

关键词：

Diagram—polymer dissolution test apparatus; Dissolution—macromolecules; Polymer disk dissolution—surface phenomena; Solvent penetration—polymer swelling;

D O I：

10.1002/jps.2600580515

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of polymer free acids, derived from ethylene maleic anhydride resins has been used to study solvent penetration into a polymer compressed disk and polymer swelling. The influence of polymer molecular weight and solvent pH on solvent penetration and polymer swelling was determined. The rate of disappearance of the hydrated layer, formed by simultaneous swelling and solvent penetration, was found to agree closely with the rate of solvent penetration. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：586 / &

共 4 条

[1] ETUDE SUR LES PHENOMENES DE DISSOLUTION DU CHLORURE DE POLYVINYLE
CORBIERE, J
TERRA, P
PARIS, R
[J]. JOURNAL OF POLYMER SCIENCE, 1952, 8 (01): : 101 - 110
[2] Flory PJ, 1953, PRINCIPLES POLYM CHE, P576
[3] POLYMERIC PHARMACEUTICAL COATING MATERIALS .I. PREPARATION AND PROPERTIES
LAPPAS, LC
MCKEEHAN, W
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (02) : 176 - &
[4] VELOCITY OF DISSOLUTION OF POLYSTYRENE
UEBERREITER, K
ASMUSSEN, F
[J]. JOURNAL OF POLYMER SCIENCE, 1957, 23 (103): : 75 - 81

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