PP60C-SRC PROTEIN-KINASE ACTIVITY IN HUMAN GASTRIC CARCINOMAS

被引：36

作者：

TAKEKURA, N ^{[1
]}

YASUI, W ^{[1
]}

YOSHIDA, K ^{[1
]}

TSUJINO, T ^{[1
]}

NAKAYAMA, H ^{[1
]}

KAMEDA, T ^{[1
]}

YOKOZAKI, H ^{[1
]}

NISHIMURA, Y ^{[1
]}

ITO, H ^{[1
]}

TAHARA, E ^{[1
]}

机构：

[1] HIROSHIMA UNIV,SCH MED,DEPT PATHOL 1,1-2-3 KASUMI,MINAMI KU,HIROSHIMA 734,JAPAN

来源：

INTERNATIONAL JOURNAL OF CANCER | 1990年 / 45卷 / 05期

关键词：

D O I：

10.1002/ijc.2910450510

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined pp60c‐src protein kinase activity in human gastric carcinoma cell lines and gastric carcinoma tissues as well as normal mucosa. pp60c‐src kinase activity was detected in all 5 carcinoma cell lines at various levels. Of 16 gastric carcinoma tissues, 8 showed higher pp60c‐src kinase activity in tumor tissues than in corresponding normal mucosa. However, the levels of expression ofpp60c‐src detected by Western blotting were not always consistent with the activities of pp60c‐src protein kinase. These findings suggest that the increase in pp60c‐src protein kinase activity might be brought about by post‐translational changes. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：847 / 851

页数：5

共 26 条

[1] THE CELLULAR SRC GENE-PRODUCT REGULATES JUNCTIONAL CELL-TO-CELL COMMUNICATION [J].

AZARNIA, R ;

REDDY, S ;

KMIECIK, TE ;

SHALLOWAY, D ;

LOEWENSTEIN, WR .

SCIENCE, 1988, 239 (4838) :398-401

[2] GASTRIN AND THE TRANSFORMING PROTEIN OF POLYOMA-VIRUS HAVE EVOLVED FROM A COMMON ANCESTOR [J].

BALDWIN, GS .

FEBS LETTERS, 1982, 137 (01) :1-5

[3] CDNA SEQUENCE AND CHROMOSOMAL LOCALIZATION OF HUMAN PLATELET-DERIVED GROWTH-FACTOR A-CHAIN AND ITS EXPRESSION IN TUMOR-CELL LINES [J].

BETSHOLTZ, C ;

JOHNSSON, A ;

HELDIN, CH ;

WESTERMARK, B ;

LIND, P ;

URDEA, MS ;

EDDY, R ;

SHOWS, TB ;

PHILPOTT, K ;

MELLOR, AL ;

KNOTT, TJ ;

SCOTT, J .

NATURE, 1986, 320 (6064) :695-699

[4] ENHANCEMENT OF CELLULAR SRC GENE-PRODUCT ASSOCIATED TYROSYL KINASE-ACTIVITY FOLLOWING POLYOMA-VIRUS INFECTION AND TRANSFORMATION [J].

BOLEN, JB ;

THIELE, CJ ;

ISRAEL, MA ;

YONEMOTO, W ;

LIPSICH, LA ;

BRUGGE, JS .

CELL, 1984, 38 (03) :767-777

[5] ACTIVATION OF PP60C-SRC PROTEIN-KINASE ACTIVITY IN HUMAN-COLON CARCINOMA [J].

BOLEN, JB ;

VEILLETTE, A ;

SCHWARTZ, AM ;

DESEAU, V ;

ROSEN, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (08) :2251-2255

[6]

BOULTER CA, 1988, ONCOGENE, V2, P207

[7] ALTERED SITES OF TYROSINE PHOSPHORYLATION IN PP60C-SRC ASSOCIATED WITH POLYOMAVIRUS MIDDLE TUMOR-ANTIGEN [J].

CARTWRIGHT, CA ;

KAPLAN, PL ;

COOPER, JA ;

HUNTER, T ;

ECKHART, W .

MOLECULAR AND CELLULAR BIOLOGY, 1986, 6 (05) :1562-1570

[8] INABILITY OF ROUS-SARCOMA VIRUS TO CAUSE SARCOMAS IN THE AVIAN EMBRYO [J].

DOLBERG, DS ;

BISSELL, MJ .

NATURE, 1984, 309 (5968) :552-556

[9] PROTEIN KINASE-C PHOSPHORYLATES PP60SRC AT A NOVEL SITE [J].

GOULD, KL ;

WOODGETT, JR ;

COOPER, JA ;

BUSS, JE ;

SHALLOWAY, D ;

HUNTER, T .

CELL, 1985, 42 (03) :849-857

[10] PLATELET-DERIVED GROWTH-FACTOR INDUCES MULTISITE PHOSPHORYLATION OF PP60C-SRC AND INCREASES ITS PROTEIN-TYROSINE KINASE-ACTIVITY [J].

GOULD, KL ;

HUNTER, T .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (08) :3345-3356

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