DEFECTIVE HYDROGEN-PEROXIDE PRODUCTION IN CHRONIC GRANULOCYTIC LEUKEMIA NEUTROPHILS

被引：14

作者：

ELMAALLEM, H ^{[1
]}

FLETCHER, J ^{[1
]}

机构：

[1] CITY HOSP NOTTINGHAM,CLIN HAEMATOL UNIT,NOTTINGHAM,ENGLAND

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1979年 / 41卷 / 01期

关键词：

D O I：

10.1111/j.1365-2141.1979.tb03680.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Summary. Hydrogen peroxide (H2O2) production by polymorphonuclear neutrophils (PMN) during phagocytosis was fluorometrically estimated over an incubation period of 80 min during which dead Candida guilliermondii were ingested. Ten patients with chronic granulocytic leukaemia (CGL) were tested and compared with 15 normal subjects. The production of H2O2 by CGL neutrophils was about 29% of normal. There was no correlation between H2O2 production and the impaired killing of Candida guilliermondii by the neutrophils of CGL patients. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：49 / 55

页数：7

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