SPECIFIC CYTOSOL RECEPTORS FOR 1,25-DIHYDROXYVITAMIN D3 IN HUMAN INTESTINE

被引：61

作者：

WECKSLER, WR ^{[1
]}

MASON, RS ^{[1
]}

NORMAN, AW ^{[1
]}

机构：

[1] SIDNEY HOSP, DEPT MED, SIDNEY 201, NEW S WALES, AUSTRALIA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1979年 / 48卷 / 04期

关键词：

D O I：

10.1210/jcem-48-4-715

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Human intestine is shown to contain a specific, high affinity cytosol receptor or binding protein for 1, 25-(OH)2-vitamin D [1, 25(OH)2D3]. This receptor is a protein which sediments at 3.5S on sucrose gradients containing 0.3 M KC1. The receptor binds 1, 25(OH)2D3 with a Kd of approximately 2 x 10‑10 M at 4°C. Competition binding studies using structural analogs of 1, 25(OH)2D3 indicate that the relative specificity of the receptor is 1, 25(OH)2D3 > 1, 24R, 25(OH)3D3 > 25OHD3 1 24R, 25(OH)2D3. © 1979 by The Endocrine Society.

引用

页码：715 / 717

页数：3

共 8 条

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[4] BIOLOGICAL-ACTIVITY OF VITAMIN-D METABOLITE 1,25-DIHYDROXYCHOLECALCIFEROL IN CHICKENS AND RATS
NORMAN, AW
WONG, RG
[J]. JOURNAL OF NUTRITION, 1972, 102 (12) : 1709 - &
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[6] THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS
SCATCHARD, G
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1949, 51 (04) : 660 - 672
[7] WECKSLER WR, 1978, J MINERAL ELECTROLYT, V1, P99
[8] WECKSLER WR, 1978, THESIS U CALIFORNIA

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