CORTICAL DIHYDROPYRIDINE BINDING-SITES AND A BEHAVIORAL SYNDROME IN MORPHINE-ABSTINENT RATS

被引：36

作者：

ANTKIEWICZMICHALUK, L ^{[1
]}

MICHALUK, J ^{[1
]}

ROMANSKA, I ^{[1
]}

VETULANI, J ^{[1
]}

机构：

[1] POLISH ACAD SCI,INST PHARMACOL,DEPT BIOCHEM,SMETNA 12,PL-31343 KRAKOW,POLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 180卷 / 01期

关键词：

Ca[!sup]2+[!/sup] channels; Morphine abstinence; Pain sensitivity;

D O I：

10.1016/0014-2999(90)90600-B

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The density of cortical [3H]nitrendipine binding sites was elevated by over 40% in rats rendered morphine-abstinent by administration of naloxone after chronic treatment with morphine. The morphine-abstinent rats had significantly shortened response latencies in the hot-plate test. Nifedipine treatment abolished the signs of abstinence and normalized the hot-plate latencies in morphine-dependent, naloxone-treated rats. The results indicate that the symptoms of abstinence are related to a functional state of cortical dihydropyridine-sensitive calcium channels. © 1990.

引用

页码：129 / 135

页数：7

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