EFFECTS OF ADMINISTRATION OF DOPAMINE-D2 AGONIST QUINPIROLE ON EXPLORATORY LOCOMOTION

被引：45

作者：

MOGENSON, GJ

WU, M

机构：

[1] Department of Physiology, The University of Western Ontario, London, Ont.

来源：

BRAIN RESEARCH | 1991年 / 551卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

NUCLEUS ACCUMBENS; DOPAMINE; QUINPIROLE; LOCOMOTOR ACTIVITY;

D O I：

10.1016/0006-8993(91)90935-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Injections of the dopamine D2 agonist quinpirole (LY 171555) into the nucleus accumbens reduced exploratory locomotion in a dose-dependent manner. Injections of the dopamine D1 agonist SKF 38393 had no effect on exploratory locomotion. The results are consistent with observations from recent electrophysiological and behavioral experiments which suggest a presynaptic action of the D2 agonist. It is proposed that quinpirole activates D2 receptors on the axon terminals of glutamatergic hippocampal-accumbens neurons that are associated with exploratory locomotion.

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收藏

页码：216 / 220

页数：5

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