A RANDOMIZED, DOSE COMPARISON STUDY OF CEFODIZIME IN THE TREATMENT OF LOWER URINARY-TRACT INFECTIONS IN WOMEN

被引:2
作者
ASBACH, HW [1 ]
机构
[1] KREISKRANKENHAUS,UROL KLIN,W-4490 LUBECK,GERMANY
关键词
D O I
10.1007/BF01645573
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
In a prospective randomized study, the efficacy and safety of 1 and 2 g of cefodizime administered as single intramuscular injections were compared in a total of 50 women having either complicated or uncomplicated lower urinary tract infections (LUTI). Bacteriological culture of urine and safety laboratory tests were performed before and after treatment. 18/25 patients in the 1 g cefodizime group and 22/25 in the 2 g cefodizime group showed satisfactory clinical and bacteriological response to treatment. The inadequately treated patients all had complicating factors on entry to the study (residual urine in six cases, a bladder malignancy in two, neurogenic bladder and diabetes mellitus with glucosuria in one case each). Cefodizime proved efficacious in female patients with uncomplicated LU-TI, as well as in those aged over 65 years, patients having mild renal insufficiency, mild glucosuria, unsuccessful oral antibiotic pretreatment or recurrent and post-operative infections. In no case were there any systemic adverse reactions to cefodizime or clinically significant changes in laboratory tests.
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页码:85 / 87
页数:3
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