CONTROLLED RELEASE MICROPARTICLES FOR VACCINE DEVELOPMENT

被引：127

作者：

OHAGAN, DT

JEFFERY, H

ROBERTS, MJJ

MCGEE, JP

DAVIS, SS

机构：

[1] Department of Pharmaceutical Sciences, University of Nottingham, Nottingham, NG7 2RD, University Park

来源：

VACCINE | 1991年 / 9卷 / 10期

关键词：

BIODEGRADABLE MICROPARTICLES; VACCINE; OVALBUMIN;

D O I：

10.1016/0264-410X(91)90295-H

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The primary and secondary sera IgG antibody responses to ovalbumin (OVA) entrapped in biodegradable poly(lactide-co-glycolide) (PLGA) microparticles were compared with the responses obtained with soluble OVA. In addition, OVA in PLGA microparticles was also administered after dispersion in an immunostimulatory vehicle, Freund's incomplete adjuvant (FIA). The primary IgG responses to OVA in microparticles/FIA were significantly greater than the responses to soluble OVA from day 14 to day 42, when booster immunizations were administered. From day 49 to the end of the study at day 84, the responses to OVA, both in microparticles alone and in microparticles/FIA, were significantly greater than the responses to soluble OVA. Nevertheless, the responses obtained for OVA in microparticles or microparticles/FIA were, in general, not as high as those obtained with OVA in Freund's complete adjuvant.

引用

页码：768 / 771

页数：4

共 21 条

[1] ALTMAN A, 1989, ADV VET SCI COMP MED, V33, P301
[2] BIODEGRADABLE MICROSPHERES .3. SOME IMMUNOLOGICAL PROPERTIES OF POLYACRYL STARCH MICROPARTICLES
ARTURSSON, P
MARTENSSON, IL
SJOHOLM, I
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1986, 75 (07) : 697 - 701
[3] VACCINES FOR THE THIRD-WORLD
BLOOM, BR
[J]. NATURE, 1989, 342 (6246) : 115 - 120
[4] EDELMAN R, 1980, REV INFECT DIS, V2, P370
[5] CONTROLLED VACCINE RELEASE IN THE GUT-ASSOCIATED LYMPHOID-TISSUES .1. ORALLY-ADMINISTERED BIODEGRADABLE MICROSPHERES TARGET THE PEYERS PATCHES
ELDRIDGE, JH
HAMMOND, CJ
MEULBROEK, JA
STAAS, JK
GILLEY, RM
TICE, TR
[J]. JOURNAL OF CONTROLLED RELEASE, 1990, 11 (1-3) : 205 - 214
[6] GIBBS CJ, 1989, 5TH INT C AIDS MONTR
[7] SINGLE-STEP IMMUNIZATION USING A CONTROLLED RELEASE, BIODEGRADABLE POLYMER WITH SUSTAINED ADJUVANT ACTIVITY
KOHN, J
NIEMI, SM
ALBERT, EC
MURPHY, JC
LANGER, R
FOX, JG
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1986, 95 (01) : 31 - 38
[8] NEW ADJUVANTS ON A POLYMETHYLMETHACRYLATE BASE
KREUTER, J
SPEISER, PP
[J]. INFECTION AND IMMUNITY, 1976, 13 (01) : 204 - 210
[9] INFLUENCE OF HYDROPHOBICITY ON THE ADJUVANT EFFECT OF PARTICULATE POLYMERIC ADJUVANTS
KREUTER, J
LIEHL, E
BERG, U
SOLIVA, M
SPEISER, PP
[J]. VACCINE, 1988, 6 (03) : 253 - 256
[10] INFLUENCE OF THE PARTICLE-SIZE ON THE ADJUVANT EFFECT OF PARTICULATE POLYMERIC ADJUVANTS
KREUTER, J
BERG, U
LIEHL, E
SOLIVA, M
SPEISER, PP
[J]. VACCINE, 1986, 4 (02) : 125 - 129

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