EFFECTS OF LIPOPOLYSACCHARIDE ON HUMAN PLACENTAL PROSTAGLANDIN-F2-ALPHA PRODUCTION IN-VITRO

被引：4

作者：

GU, W ^{[1
]}

RICE, GE ^{[1
]}

BRENNECKE, SP ^{[1
]}

机构：

[1] ROYAL HOSP WOMEN, DEPT PERINATAL MED, CARLTON, VIC 3002, AUSTRALIA

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1994年 / 50卷 / 06期

关键词：

D O I：

10.1016/0952-3278(94)90239-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of bacterial endotoxin (lipopolysaccharide, LPS), on the release of prostaglandin F-2 alpha (PGF(2 alpha)) from human placental explants was investigated. Both LPS and calcium ionophore A23187 stimulated PGF(2 alpha) release (p < 0.05). Placental explants, either exposed to LPS and A23187 simultaneously or primed by LPS before A23187 stimulation, resulted in similar increased PGF(2 alpha) releases, which were higher than the level of LPS alone. The data suggest LPS could increase basal PGF(2 alpha) release from human placenta, combined with A23187 it may act on PG synthase as well in favour of PGF(2 alpha) formation.

引用

页码：311 / 315

页数：5

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