NEW METABOLITES FROM THE SOUTH-AFRICAN SOFT CORAL CAPNELLA THYRSOIDEA

被引：39

作者：

HOOPER, GJ ^{[1
]}

DAVIESCOLEMAN, MT ^{[1
]}

机构：

[1] RHODES UNIV,SCH PHARMACEUT SCI,GRAHAMSTOWN 6140,SOUTH AFRICA

来源：

TETRAHEDRON | 1995年 / 51卷 / 36期

关键词：

D O I：

10.1016/0040-4020(95)00570-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ethyl acetate extracts of two phenotypic color variants of the endemic South African soft coral, Capnella thyrsoidea yielded the known steroid 5 alpha-pregna-1,20-dien-3-one (1) and a further six new compounds, 16 beta-hydroxy-5 alpha-pregna-1,20-dien-3-one 16-acetate (2), 3 alpha,16 beta-dihydroxy-5 alpha-pregna-1,20-diene 3,16-diacetate (3) and four xenicane diterpenes, the tsitsixenicins A-D (6, 10 - 12). Standard spectroscopic methods were used to determine the structures and stereochemistry of these compounds. This is the first reported isolation of xenicane diterpenes from the soft coral family Nephtheiidae. Compounds 6 and 10 inhibit superoxide production in both rabbit and human cell neutrophils.

引用

页码：9973 / 9984

页数：12

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