NEURASTHENIC FATIGUE, CHEMICAL-SENSITIVITY AND GABA-A RECEPTOR TOXINS

被引：23

作者：

CORRIGAN, FM

MACDONALD, S

BROWN, A

ARMSTRONG, K

ARMSTRONG, EM

机构：

[1] Argyll and Bute Hospital, Lochgilphead, Argyll

[2] The Surgery Connel, Argyll

来源：

MEDICAL HYPOTHESES | 1994年 / 43卷 / 04期

关键词：

D O I：

10.1016/0306-9877(94)90065-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Following observation of fatigue syndromes in people who have been occupationally exposed to pesticides and insecticides which exert their toxicity through the GABAa receptor, we have formulated the hypothesis that fatigue syndromes in general may be secondary to altered sensitivity of the GABAa receptor. We discuss the possible involvement of organochlorine compounds which are widespread in the environment. Organophosphate compounds may have similar toxic effects through damaged cholinergic input to the dentate gyrus of the hippocampus where cholinergic and GABAergic transmission are closely linked.

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页码：195 / 200

页数：6

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