SIMPLE RAPID HYDROLYSIS OF ACETYL PROTECTING GROUPS IN THE FDG SYNTHESIS USING CATION-EXCHANGE RESINS

被引：17

作者：

MULHOLLAND, GK

机构：

[1] Indiana University School of Medicine, Department of Radiology, Indianapolis, IN 46202, 975 W. Walnut Street

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1995年 / 22卷 / 01期

关键词：

D O I：

10.1016/0969-8051(94)E0068-T

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A new solid phase method for hydrolysis of acetyl groups from the intermediate 2-[F-18]fluoro-2-deoxyglucose tetraacetate ([F-18]FDG-Ac-4) was developed. Fast cleavage occurs with Dowex 50 sulfonic acid resin (H+ form) at similar to lOO degrees C in the absence of bulk water. [F-18]FDG-Ac-4 reaction mixtures were efficiently converted to neutral aqueous solutions of pure FDG in 10-15 min. The method avoids problems associated with liquid acids and can be easily integrated into existing [F-18]FDG procedures.

引用

页码：19 / 23

页数：5

共 11 条

[1] ION CHROMATOGRAPHIC ANALYSIS OF HIGH SPECIFIC ACTIVITY (18)FDG PREPARATIONS AND DETECTION OF THE CHEMICAL IMPURITY 2-DEOXY-2-CHLORO-D-GLUCOSE [J].

ALEXOFF, DL ;

CASATI, R ;

FOWLER, JS ;

WOLF, AP ;

SHEA, C ;

SCHLYER, DJ ;

SHIUE, CY .

APPLIED RADIATION AND ISOTOPES, 1992, 43 (11) :1313-1322

[2]

HAMACHER K, 1986, J NUCL MED, V27, P235

[3]

HO PT, 1978, TETRAHEDRON LETT, P1623

[4]

MITSCHKER A, 1988, HETEROGENEOUS CATALY, P61

[5] POLYMER-SUPPORTED PHASE-TRANSFER CATALYSTS - HIGH CATALYTIC ACTIVITY OF AMMONIUM AND PHOSPHONIUM QUATERNARY-SALTS BONDED TO A POLYSTYRENE MATRIX [J].

MOLINARI, H ;

MONTANARI, F ;

QUICI, S ;

TUNDO, P .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1979, 101 (14) :3920-3927

[6]

MULHOLLAND GK, 1994, IN PRESS J LAB COMP

[7] COMPUTER-CONTROLLED RADIOCHEMICAL SYNTHESIS - A CHEMISTRY PROCESS-CONTROL UNIT FOR THE AUTOMATED PRODUCTION OF RADIOCHEMICALS [J].

PADGETT, HC ;

SCHMIDT, DG ;

LUXEN, A ;

BIDA, GT ;

SATYAMURTHY, N ;

BARRIO, JR .

APPLIED RADIATION AND ISOTOPES, 1989, 40 (05) :433-&

[8]

Pietrzyk D. J., 1976, CRC CRIT R ANAL CHEM, V6, P131

[9] A REFINED METHOD FOR THE REMOVAL OF THE METHOXYMETHYL (MOM) PROTECTING GROUP FOR CARBINOLS WITH ACIDIC ION-EXCHANGE RESIN [J].

SETO, H ;

MANDER, LN .

SYNTHETIC COMMUNICATIONS, 1992, 22 (19) :2823-2828

[10]

Sherrington D. C., 1988, SYNTHESIS SEPARATION

← 1 2 →