CATALYTIC ASYMMETRIC-SYNTHESIS OF PROPRANOLOL AND METOPROLOL USING A LA-LI-BINOL COMPLEX

被引：28

作者：

SASAI, H ^{[1
]}

SUZUKI, T ^{[1
]}

ITOH, N ^{[1
]}

SHIBASAKI, M ^{[1
]}

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 1995年 / 9卷 / 5-6期

关键词：

LANTHANUM; ASYMMETRIC CATALYST; BIMETALLIC CATALYST; NITROALDOL; BETA-BLOCKERS;

D O I：

10.1002/aoc.590090508

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The La-Li-(R)-BINOL complex prepared from either lanthanum(III) chloride [LaCl3 . 7H(2)O] or [La(O-i-Pr)(3)] has made possible effective catalytic asymmetric syntheses of therapeutically important beta-blockers such as propranolol and metoprolol. The possible stereochemical course of asymmetric nitroaldol reactions has been also clarified.

引用

页码：421 / 426

页数：6

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