STABILITY DETERMINATION OF HOMATROPINE HYDROBROMIDE BY DIRECT CERIMETRIC TITRATION

Using ceric nitrate as the titrant, the difference in titer between saponified and unhydrolyzed aliquots of homatropine solutions provides a measure of intact drug in the presence of its mandelic acid hydrolysis product. The titration is conducted on chilled solutions to circumvent interference by tropine, the other hydrolysis product, which is slowly oxidized by the titrant at room temperature. The proposed procedure is highly selective for the drug in the presence of its hydrolysis products, other tropine esters, and most other organic nitrogenous bases. The cerimetric titration method is rapid, absolute, and stability indicating. Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company