LIPID PACKING AND TRANSBILAYER ASYMMETRIES OF MIXED LIPID VESICLES

被引：101

作者：

CARNIE, S ^{[1
]}

ISRAELACHVILI, JN ^{[1
]}

PAILTHORPE, BA ^{[1
]}

机构：

[1] AUSTRALIAN NATL UNIV, RES SCH BIOL SCI, INST ADV STUDIES, DEPT NEUROBIOL, CANBERRA 2601, ACT, AUSTRALIA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 554卷 / 02期

关键词：

(Lipid bilayer vesicle); Lysophosphatidylcholine; Membrane asymmetry; Membrane packing; Phosphatidylcholine;

D O I：

10.1016/0005-2736(79)90375-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Predictions, based on a previously developed theory, of the radii and asymmetric lipid distribution of mixed phosphatidylcholine/lysophosphatidylcholine and phosphatidylcholine/cholesterol vesicles of variable composition are presented. The results compare well with available experimental data, except for cis-unsaturated phosphatidylcholine/cholesterol vesicles at high concentrations of cholesterol. It is concluded that specific lipid-lipid interactions need not be invoked for saturated and trans-unsaturated phosphatidylcholine mixed with lysophosphatidylcholine or cholesterol. A discussion of the effect of packing stresses on induced flip-flop and non-spherical vesicles is also presented. © 1979.

引用

页码：340 / 357

页数：18

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