PROTECTION AGAINST THE LETHAL EFFECTS OF CROTALUS-DURISSUS-TERRIFICUS (SOUTH-AMERICAN RATTLESNAKE) VENOM IN ANIMALS IMMUNIZED WITH CROTOXIN

被引：11

作者：

FREITAS, TV

FORTESDIAS, CL

DINIZ, CR

机构：

[1] Fundação Ezequiel Dias, Belo Horizonte, MG

来源：

TOXICON | 1990年 / 28卷 / 12期

关键词：

D O I：

10.1016/0041-0101(90)90162-Z

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

T. V. Freitas, C. L. Fortes-Dias and C. R. Diniz. Protection against the lethal effects of Crotalus durissus terrificus (South American rattlesnake) venom in animals immunized with crotoxin. Toxicon 28, 1491-1496, 1990.-Mice and rabbits were immunized against crotoxin (the neurotoxic component isolated from Crotalus durissus terrificus venom) using small amounts of antigen in a water-in-oil emulsion. Following boosting (three times at 21-day intervals) a high titre of antibodies against crotoxin was obtained. Crotoxin immunoglobulin G antibody recognizes whole venom antigen at a level comparable with that of crotoxin antigen, using the ELISA method for antibody detection. The antibodies generated by crotoxin were capable of providing 100% protection against challenge with 11 and 50 i.p. ld50 doses of whole venom in mice. When 100 i.p. ld50 doses of whole venom were injected survival was 77.8%. © 1990.

引用

页码：1491 / 1496

页数：6

共 24 条

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