A PRENYLFLAVONE, ARTONIN-E, AS ARACHIDONATE 5-LIPOXYGENASE INHIBITOR

被引：51

作者：

REDDY, GR

UEDA, N

HADA, T

SACKEYFIO, AC

YAMAMOTO, S

HANO, Y

AIDA, M

NOMURA, T

机构：

[1] UNIV TOKUSHIMA,SCH MED,DEPT BIOCHEM,KURAMOTO CHO,TOKUSHIMA 770,JAPAN

[2] TOHO UNIV,FAC PHARMACEUT SCI,FUNABASHI,CHIBA 274,JAPAN

来源：

BIOCHEMICAL PHARMACOLOGY | 1991年 / 41卷 / 01期

关键词：

D O I：

10.1016/0006-2952(91)90018-Z

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Several naturally occurring prenylflavones were tested for their inhibitory actions on arachidonate 5-lipoxygenase purified from porcine leukocytes. Of the compounds tested, artonin E (5'-hydroxymorusin) exhibited the most potent inhibition of arachidonate 5-lipoxygenase (IC50 = 0.36-mu-M). Arachidonate 12-lipoxygenases purified from porcine leukocytes and human platelets, 15-lipoxygenase from rabbit reticulocytes and fatty acid cyclooxygenase from bovine vesicular glands were inhibited by the compound only at higher concentrations (IC50 = 2.3, 11, 5.2 and 2.5-mu-M, respectively).

引用

页码：115 / 118

页数：4

共 25 条

[1] CHELATING AND FREE-RADICAL SCAVENGING MECHANISMS OF INHIBITORY-ACTION OF RUTIN AND QUERCETIN IN LIPID-PEROXIDATION [J].