CHEMOENZYMATIC SYNTHESIS OF AMINO-ACIDS AND DERIVATIVES

被引：22

作者：

SCHOEMAKER, HE

BOESTEN, WHJ

KAPTEIN, B

HERMES, HFM

SONKE, T

BROXTERMAN, QB

VANDENTWEEL, WJJ

KAMPHUIS, J

机构：

[1] DSM Research, Bio-organic Chemistry section, 6160 MD Geleen

来源：

PURE AND APPLIED CHEMISTRY | 1992年 / 64卷 / 08期

关键词：

D O I：

10.1351/pac199264081171

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A short overview is given of new developments in the chemo-enzymatic synthesis of amino acids. Amino acid resolution procedures based on stereoselective enzymatic hydrolysis of amino acid amides have been developed. Two enzymes, an aminopeptidase from Pseudomonas putida and an amidase from Mycobacterium neoaurum have been purified to homogeneity. In addition, methods for the stereoselective synthesis of alpha-alkyl-substituted hydroxy acids are given.

引用

页码：1171 / 1175

页数：5

共 11 条

[1] N-FORMYLCARBAMOYLASPARTAME, A NEW ASPARTAME-LIKE SWEETENER - SYNTHESIS AND STUDIES ON STABILITY AND BIOLOGICAL PROPERTIES [J].

BOESTEN, WHJ ;

DASSEN, BHN ;

KLEINJANS, JCS ;

VANAGEN, B ;

VANDERWAL, S ;

DEVRIES, NK ;

SCHOEMAKER, HE ;

MEIJER, EM .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1991, 39 (01) :154-158

[2]

BROXTERMAN QB, 1990, OPPORTUNITIES IN BIOTRANSFORMATIONS, P148

[3]

Kamphuis J, 1990, Adv Biochem Eng Biotechnol, V42, P133

[4]

KLOOSTERMAN M, 1990, GBF MONOGRAPHS, V16, P187

[5] PIG-LIVER ESTERASE CATALYZED HYDROLYZES OF RACEMIC ALPHA-SUBSTITUTED ALPHA-HYDROXY ESTERS [J].

MOORLAG, H ;

KELLOGG, RM ;

KLOOSTERMAN, M ;

KAPTEIN, B ;

KAMPHUIS, J ;

SCHOEMAKER, HE .

JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (23) :5878-5881

[6]

MOORLAG H, IN PRESS RECL TRAV C

[7] THE SYNTHESIS OF L(-) AND D(+) LUPINIC ACID [J].

SHADID, B ;

VANDERPLAS, HC ;

BOESTEN, WHJ ;

KAMPHUIS, J ;

MEIJER, EM ;

SCHOEMAKER, HE .

TETRAHEDRON, 1990, 46 (03) :913-920

[8]

TONIOLO C, 1991, INT J PEPT PROT RES, V38, P242

[9]

TONIOLO C, 1991, Peptide Research, V4, P66

[10] 1ST OBSERVATION OF A HELICAL PEPTIDE CONTAINING A CHIRAL RESIDUE WITHOUT A PREFERRED SCREW SENSE [J].

VALLE, G ;

CRISMA, M ;

TONIOLO, C ;

BEISSWENGER, R ;

RIEKER, A ;

JUNG, G .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (17) :6828-6833

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