PROPERTIES OF [TAURINE-H-3 RELEASE FROM CRUDE SYNAPTOSOMAL FRACTIONS OF RAT CEREBRAL-CORTEX

被引：19

作者：

PLACHETA, P ^{[1
]}

SINGER, E ^{[1
]}

SIEGHART, W ^{[1
]}

KAROBATH, M ^{[1
]}

机构：

[1] VIENNA UNIV, PSYCHIAT KLIN, DEPT BIOCHEM PHARMACOL, A-1010 VIENNA, AUSTRIA

来源：

NEUROCHEMICAL RESEARCH | 1979年 / 4卷 / 06期

关键词：

D O I：

10.1007/BF00964467

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The release of previously accumulated [3H]taurine and [14C]GABA from crude synaptosomal (P2) fractions isolated from rat cerebral cortex was studied using a superfusion system. The spontaneous efflux of [3H]taurine and [14C]GABA was stimulated by elevated concentrations of K+ (15-133 mM) in a concentration-dependent manner. This K+-stimulated release of [14C]GABA but not of [3H]taurine was enhanced in the presence of Ca2+. However, addition of 3 mM Ca2+ to the superfusion medium in the presence of the ionophore A 23187 resulted in a stimulation of the release of both [3H]taurine and [14C]GABA. These results are discussed in connection with the cellular localization of tourine in the central nervous system. © 1979 Plenum Publishing Corporation.

引用

页码：703 / 712

页数：10

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