EFFECT OF ANISOMYCIN ON THE DEVELOPMENT OF RAPID TOLERANCE TO ETHANOL-INDUCED MOTOR IMPAIRMENT

被引:11
作者
BITRAN, M
KALANT, H
机构
[1] UNIV TORONTO,DEPT PHARMACOL,MED SCI BLDG,TORONTO M5S 1A8,ONTARIO,CANADA
[2] ADDICT RES FDN ONTARIO,TORONTO M5S 2S1,ON,CANADA
关键词
ETHANOL; MOTOR IMPAIRMENT; RAPID TOLERANCE; RAT; ANISOMYCIN;
D O I
10.1016/0091-3057(93)90109-7
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Male Wistar rats given a single moderate dose (1.7 g/kg, IP) of ethanol (EtOH), followed by six trials on the moving belt apparatus during the next hour, showed functional tolerance to the motor-impairing effects of a second dose given 24 h later if the first EtOH was preceded and followed by an injection of saline. The same EtOH dose and intoxicated practice did not produce tolerance if the saline injections were replaced by two doses of anisomycin (60 mg/kg each, SC) 15 min before and 105 min after the first dose of EtOH. This finding suggests that rapid tolerance, like chronic tolerance, requires de novo synthesis of protein during a short period immediately related to the test experience.
引用
收藏
页码:225 / 228
页数:4
相关论文
共 22 条
[1]   LEARNING FACTOR IN RAPID TOLERANCE TO ETHANOL-INDUCED MOTOR IMPAIRMENT [J].
BITRAN, M ;
KALANT, H .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1991, 39 (04) :917-922
[2]   PROTEIN KINASE-C MEDIATES THE EFFECT OF VASOPRESSIN IN PITUITARY CORTICOTROPHS [J].
CARVALLO, P ;
AGUILERA, G .
MOLECULAR ENDOCRINOLOGY, 1989, 3 (12) :1935-1943
[3]  
CRABBE JC, 1979, J PHARMACOL EXP THER, V208, P128
[4]   THE ROLE OF CONDITIONAL DRUG RESPONSES IN TOLERANCE TO THE HYPOTHERMIC EFFECTS OF ETHANOL [J].
CROWELL, CR ;
HINSON, RE ;
SIEGEL, S .
PSYCHOPHARMACOLOGY, 1981, 73 (01) :51-54
[5]   INFLUENCE OF DURATION OF PROTEIN-SYNTHESIS INHIBITION ON MEMORY [J].
FLOOD, JF ;
ROSENZWEIG, MR ;
BENNETT, EL ;
ORME, AE .
PHYSIOLOGY & BEHAVIOR, 1973, 10 (03) :555-562
[6]   RAPID ONSET OF ETHANOL TOLERANCE IN WISTAR RATS FOLLOWING INTENSIVE PRACTICE ON THE MOVING-BELT TASK [J].
GALLAHER, EJ ;
LOOMIS, TA .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1979, 48 (03) :415-424
[7]  
KALANT H, 1971, PHARMACOL REV, V23, P135
[8]   NMDA ANTAGONIST INHIBITS RAPID TOLERANCE TO ETHANOL [J].
KHANNA, JM ;
WU, PH ;
WEINER, J ;
KALANT, H .
BRAIN RESEARCH BULLETIN, 1991, 26 (04) :643-645
[9]   CONDITIONED TOLERANCE TO THE HYPOTHERMIC EFFECT OF ETHYL-ALCOHOL [J].
LE, AD ;
POULOS, CX ;
CAPPELL, H .
SCIENCE, 1979, 206 (4422) :1109-1110
[10]  
LE AD, 1992, PSYCHOPHARMACOLOGY B, V6, P572