DETERMINATION OF ENANTIOMERIC PURITY OF (S)-CARBORANYLALANINE USING CAPILLARY COLUMN SUPERCRITICAL-FLUID CHROMATOGRAPHY

被引：13

作者：

PETERSSON, P

MALMQUIST, J

MARKIDES, KE

SJOBERG, S

机构：

[1] UNIV UPPSALA,DEPT ORGAN CHEM,S-75121 UPPSALA,SWEDEN

[2] UNIV UPPSALA,DEPT ANALYT CHEM,S-75121 UPPSALA,SWEDEN

来源：

JOURNAL OF CHROMATOGRAPHY A | 1994年 / 670卷 / 1-2期

关键词：

D O I：

10.1016/0021-9673(94)80301-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Carboranylalanine, the o-carborane analogue of phenylalanine, is a potential candidate for boron neutron capture therapy of cancer. In this paper a method is described for the determination of enantiomeric purity of (S)-carboranylalanine as the (N-trifluoroacetyl)propylester using open tubular column supercritical fluid chromatography with a chiral stationary phase consisting of permethyl-beta-cyclodextrin methyloctylsiloxane.

引用

收藏

页码：239 / 242

页数：4

相关论文

共 23 条

[1] HELIFLEX CHIRASIL-VAL - GC OF AMINO-ACID ENANTIOMERS [J].

ABE, I ;

KURAMOTO, S ;

MUSHA, S .

JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY & CHROMATOGRAPHY COMMUNICATIONS, 1983, 6 (07) :366-370

[2]

ANDERSSON A, 1992, PROGRESS IN NEUTRON CAPTURE THERAPY FOR CANCER, P41

[3]

BARTH RF, 1992, CANCER-AM CANCER SOC, V70, P2995

[4] PRESENT STATUS OF BORON NEUTRON-CAPTURE THERAPY [J].

CARLSSON, J ;

SJOBERG, S ;

LARSSON, BS .

ACTA ONCOLOGICA, 1992, 31 (08) :803-813

[5] SYNTHESIS OF [4-CARBORANYLALANINE, 5-LEUCINE]-ENKEPHALIN - (INCLUDING AN IMPROVED PREPARATION OF TERT-BUTOXYCARBONYL-L-ORTHO-CARBORANYLALANINE, NEW DERIVATIVES OF L-PROPARGYLGLYCINE, AND A NOTE ON MELANOTROPIC AND OPIATE RECEPTOR-BINDING CHARACTERISTICS) [J].

FAUCHERE, JL ;

LEUKART, O ;

EBERLE, A ;

SCHWYZER, R .

HELVETICA CHIMICA ACTA, 1979, 62 (05) :1385-1395

[6] HORMONE-RECEPTOR INTERACTIONS - CARBORANYLALANINE (CAR) AS A PHENYLALANINE ANALOG - REACTIONS WITH CHYMOTRYPSIN [J].

FISCHLI, W ;

LEUKART, O ;

SCHWYZER, R .

HELVETICA CHIMICA ACTA, 1977, 60 (03) :959-963

[7] PREPARATION AND PROPERTIES OF INCLUSION COMPLEXES OF 1,2-DICARBADODECABORANE(12) WITH CYCLODEXTRINS [J].

HARADA, A ;

TAKAHASHI, S .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1988, (20) :1352-1353

[8] THE ROLE OF CHEMISTRY IN THE DEVELOPMENT OF BORON NEUTRON-CAPTURE THERAPY OF CANCER [J].

HAWTHORNE, MF .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1993, 32 (07) :950-984

[9] NUMERICAL-INTEGRATION OF COMPLEX CHROMATOGRAMS USING FITTED GAUSSIAN FUNCTIONS [J].

KOSKINEN, MO ;

KOSKINEN, LK .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1993, 16 (15) :3171-3184

[10]

LEE ML, ANAL SUPERCRITICAL F, P172