HEALING IMPAIRMENT OF OPEN WOUNDS BY SKIN IRRADIATION

被引:21
作者
BERNSTEIN, EF
HARISIADIS, L
SALOMON, GD
HARRINGTON, F
MITCHELL, JB
UITTO, J
GLATSTEIN, E
RUSSO, A
机构
[1] UNIV TEXAS, SW MED SCH, DEPT RADIAT ONCOL, DALLAS, TX 75230 USA
[2] NIH, RADIAT ONCOL BRANCH, BETHESDA, MD 20892 USA
[3] GEORGE WASHINGTON UNIV, MED CTR, RADIAT THERAPY SECT, WASHINGTON, DC 20037 USA
来源
JOURNAL OF DERMATOLOGIC SURGERY AND ONCOLOGY | 1994年 / 20卷 / 11期
关键词
D O I
10.1111/j.1524-4725.1994.tb03200.x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND. Ionizing radiation is frequently used for the treatment of malignancy. Sequelae of therapeutic radiation frequently present clinical problems in the form of poor wound healing and easy injury of treated tissue in response to mild trauma. OBJECTIVE. We describe a radiation-impaired wound healing model in guinea pigs, developed to determine the effect of cutaneous irradiation on wound contraction. METHODS. Guinea pigs were anesthetized and a flap of skin was isolated and treated with x-rays to 18 Gy. Circular wounds of identical size were made in irradiated and control skin, and average wound size was recorded. Results. Our results demonstrate that a statistically significant wound healing deficit is produced in open wounds by surface irradiation of skin. CONCLUSION. Radiation of skin results in slower healing of open wounds, and provides an in vivo system for evaluation of topical dressings and growth factors in radiation-impaired wounds.
引用
收藏
页码:757 / 760
页数:4
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